In this study, the investigators will recruit a cohort of elderly Black and Hispanic patients with heart failure to define the number of patients who have cardiac amyloidosis by utilizing highly sensitive heart imaging and blood tests. The investigators will also explore differences in genetics and sex as they relate to heart failure disease progression in cardiac amyloidosis.
Name: 99mTc-PYP
Description: The prevalence of ATTR CA will be defined by the number of cases with significant myocardial retention of Tc-99 PYP including both ATTRwt and ATTRm CA as a percentage of total enrollment.
Measure: Prevalence of Transthyretin Cardiac Amyloidosis in Caribbean Hispanics and Blacks with heart failure (HF) Time: 5 yearsDescription: Among subjects with ATTR-CA we will determine the prevalence of ATTRwt and ATTRm from the Val122Ile mutation in Blacks and Caribbean Hispanics
Measure: Prevalence of ATTRwt and ATTRm in Blacks and Caribbean Hispanics Time: 5 yearsDescription: The prevalence of ATTR cardiac amyloidosis will be calculated among men and women enrolled in this study
Measure: Sex distribution of ATTR cardiac amyloidosis Time: 5 yearsDescription: In the ATTR CA group alone, a composite time-to-first-event endpoint at 1-year of death, heart failure hospitalization, or 30% decline in 6-minute hall walk will be compared between ATTRwt and ATTRm subjects.
Measure: Disease progression in ATTRwt compared to ATTRm Time: 5 yearsDescription: Retinol binding protein 4 (RBB4) will be measured in urine.
Measure: RBP4 in Urine Time: 5 yearsCohort
There is one SNP
Among subjects with ATTR-CA we will determine the prevalence of ATTRwt and ATTRm from the Val122Ile mutation in Blacks and Caribbean Hispanics. --- Val122Ile ---
For hATTR, a substitution of isoleucine for valine (Val122Ile) is the most frequent TTR mutation in the US, observed exclusively in Black Americans with an allele frequency of 3.4%. --- Val122Ile ---