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Report for Clinical Trial NCT01345877

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Pain Sensitivity in Acute Inflammatory Pain - Gender Differences and Validity of Sensory Tests

Pain is a complex experience influenced by gender and genetics, and, by psychosocial and sensory experiences. Pain sensitivity is thus highly variable between individuals. In the present study we evaluate individualsĀ“ pain perception in response to a number of different pain stimuli in 100 healthy volunteers (50 females and 50 males). The data will allow us to assess pain sensitivity, to predict pain responses and to investigate gender related differences in pain perception. A second aim is to evaluate the robustness of the different pain-tests since the tests are repeated with an interval of 2-4 weeks.

NCT01345877 Healthy Volunteers Are Studied

1 Interventions

Name: first degree cutaneous burn injury

Description: application of thermode (5 x 2.5 cm) to lower leg temperature 47.0 C, 420 s
Type: Procedure
Group Labels: 1


Primary Outcomes

Measure: pain following burn injury

Time: from baseline to 420 s after burn injury

Secondary Outcomes

Measure: thermal thresholds

Time: followed for 180 min after burn injury

Measure: tactile thresholds

Time: followed for 180 min after burn injury

Measure: pressure algometry assessments

Time: 95 min prior to burn injury

Measure: DNIC-efficiency

Time: 45 min before burn injury

Measure: cold pressor test

Time: 85 min before burn injury

Measure: HADS score

Time: 2 hours before the burn injury

Measure: PCS ratings

Time: 2 hours before the burn injury

Measure: A118G SNP

Time: 8 months after inclusion completed

Purpose: Basic Science

Allocation: N/A

Single Group Assignment

There is one SNP


1 A118G

A118G SNP. --- A118G ---

Psychophysical assessments following induction of a first degree burn injury (47.0 C, 420 s, 12.5, lower leg) include: - pain during induction of burn injury - thermal thresholds - tactile thresholds - electrical thresholds - areas of secondary hyperalgesia - pressure algometric assessments - assessment of Diffuse Noxious Inhibitory Control (DNIC) efficiency - assessment of (DNIC) using cold pressor test Psychological assessments include: - HADS (Hospital Anxiety and Depression Scale) - PCS (Pain Catastrophizing Scale) - vulnerability score Genetics include: - A118G SNP Demographics include: - gender - height - weight --- A118G ---

HPO Nodes