SNPMiner Trials by Shray Alag


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Report for Clinical Trial NCT01016444

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

β2AR Polymorphisms and Albuterol Responsiveness in Acute Asthma

The hypothesis to be tested is that acutely ill asthmatics who do not resolve their attacks following standard doses of albuterol and require admission to hospital have single nucleotide polymorphisms of their B2 adrenergic receptors that lower B2 agonist responsivity.

NCT01016444 Acute Asthma
MeSH:Asthma
HPO:Asthma


Primary Outcomes

Measure: B2AR polymorphisms associated with albuterol responsiveness in acute asthma.

Time: ~ 1 hour following 3 doses of albuterol Q 20 min

Secondary Outcomes

Measure: B2AR haplotypes

Time: ~ 1hr post 3 doses of albuterol

Time Perspective: Prospective

Case Control


There are 2 SNPs

SNPs


1 G16R

The results of this study will demonstrate whether Gly16Arg or Gln27Glu genotypes and/or β2AR haplotypes are associated with the response to albuterol in patients who experience acute episodes of asthma and whether genotype pattern varies between different clinical phenotypes. --- Gly16Arg ---


2 Q27E

The results of this study will demonstrate whether Gly16Arg or Gln27Glu genotypes and/or β2AR haplotypes are associated with the response to albuterol in patients who experience acute episodes of asthma and whether genotype pattern varies between different clinical phenotypes. --- Gly16Arg --- --- Gln27Glu ---



HPO Nodes


HPO: