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Report for Clinical Trial NCT03284684

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Kinetics of Perioperative Circulating DNA in Cancer Surgery

The aim of this study was to determine the kinetics of perioperative circulating DNA in three types of cancer. This first step will enable further studies comparing the potential impact of certain techniques or anesthetic products on cancer surgery.

NCT03284684 Breast Cancer Prostate Cancer Colon Cancer
MeSH:Colonic Neoplasms
HPO:Colon cancer Neoplasm of the colon

1 Interventions

Name: Blood test

Description: plasma concentration of circulating DNA of specific genes
Type: Other
Group Labels: 1

circulating DNA plasma level test


Primary Outcomes

Description: ng/mL in plasma

Measure: Change in concentration of total mutant circulating DNA

Time: Nine timepoints between Day-1 to Day 3

Description: ng/mL in plasma

Measure: Change in proportion of mutant circulating DNA

Time: Nine timepoints between Day-1 to Day 3

Description: concentration of long ACTB ctDNA fragments/concentration of short ACTB ctDNA fragments

Measure: Change in integrity index of circulating DNA for ACTB gene

Time: Nine timepoints between Day-1 to Day 3

Description: concentration of long KRAS ctDNA fragments/concentration of short KRAS ctDNA fragments

Measure: Change in integrity index of circulating DNA for KRAS gene

Time: Nine timepoints between Day-1 to Day 3

Secondary Outcomes

Description: ng/mL in plasma

Measure: Change in plasma concentration of long (~ 290bp) fragments of ACTB gene

Time: Nine timepoints between Day-1 to Day 3

Description: ng/mL in plasma

Measure: Change in plasma concentration of short (~ 145bp) fragments of KRAS gene

Time: Nine timepoints between Day-1 to Day 3

Description: ng/mL in plasma

Measure: Change in plasma concentration of long (~ 300bp) fragments of KRAS gene

Time: Nine timepoints between Day-1 to Day 3

Description: ng/mL in plasma

Measure: Change in plasma concentration of mutant KRAS DNA fragments

Time: Nine timepoints between Day-1 to Day 3

Description: ng/mL in plasma

Measure: Change in plasma concentration of BRAF DNA fragments with V600E mutation

Time: Nine timepoints between Day-1 to Day 3

Time Perspective: Prospective

Case-Only


There is one SNP

SNPs


1 V600E

Change in plasma concentration of BRAF DNA fragments with V600E mutation. --- V600E ---



HPO Nodes


HPO: