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Report for Clinical Trial NCT04213313

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Consecutive, Case Control Study of Association Between Single Nucleotide Polymorphism of SP-D and Susceptibility and Prognosis of Infectious Keratitis

This study explores the association between single nucleotide polymorphism (Met11Thr) of surfactant protein D(SP-D) and susceptibility and prognosis of infectious keratitis.Met11Thr of SP-D of patients with keratitis and normal controls were compared.Allele and genotype frequencies of patients with keratitis and normal controls were determined by polymerase chain reaction with sequence specific primers(PCR-SSPs) .SP-D gene polymorphism of patients with keratitis and normal controls was detected by Sanger sequencing

NCT04213313 Infectious Keratitis
MeSH:Communicable Diseases Infection Keratitis
HPO:Keratitis

5 Interventions

Name: Treatment of bacterial keratitis

Description: 0.3% Levofloxacin Eye Drops or 0.3% Tobramycin Eye Drops QID
Type: Drug
Group Labels: 1

Infectious Keratitis Group

Name: Treatment of fungal keratitis

Description: 1% Fluconazole Eye Drops or 0.25% Amphotericin B Eye Drops QID
Type: Drug
Group Labels: 1

Infectious Keratitis Group

Name: Treatment of viral keratitis

Description: 0.1% Acyclovir eye drops QID ,Ganciclovir gel QN,Famiclovir tablets 0.25g TID
Type: Drug
Group Labels: 1

Infectious Keratitis Group

Name: corneal scraping

Description: culture and sensitivity of corneal ulcerated infiltrating edge tissue
Type: Diagnostic Test
Group Labels: 1

Infectious Keratitis Group

Name: Sequencing

Description: polymerase chain reaction with sequence specific primers(PCR-SSP) and Sanger sequencing
Type: Other
Group Labels: 2

Control Group Infectious Keratitis Group


Primary Outcomes

Description: Base type of SNP(rs721917):(Met and Thr)

Measure: Base type

Time: before the treatment

Description: Genotype of SNP(rs721917):( Met /Met , Thr/Thr and Met/Thr)

Measure: Genotype

Time: before the treatment

Secondary Outcomes

Description: Grading of Keratitis: cornea:transparency ,edema,turbidity,perforation conjunctiva: hyperaemia blephar:inflammation

Measure: Grading of Keratitis

Time: before the treatment

Time Perspective: Prospective

Case-Control


There is one SNP

SNPs


1 M11T

Association Between SNP of SP-D and Susceptibility and Prognosis of Infectious Keratitis This study explores the association between single nucleotide polymorphism (Met11Thr) of surfactant protein D(SP-D) and susceptibility and prognosis of infectious keratitis.Met11Thr of SP-D of patients with keratitis and normal controls were compared.Allele and genotype frequencies of patients with keratitis and normal controls were determined by polymerase chain reaction with sequence specific primers(PCR-SSPs) .SP-D gene polymorphism of patients with keratitis and normal controls was detected by Sanger sequencing Base type. --- Met11Thr ---



HPO Nodes


HPO: