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Report for Clinical Trial NCT03444090

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Impacts of Inspection During Instrument Insertion on Colonoscopy Quality: a Prospective Randomized Controlled Trial

Small colon polyps which are found during colonoscopy insertion are sometimes difficult to find during withdrawal and thus missed. The investigators aim to evaluate the differences of colon polyp/adenoma detection rates of patients undergoing additional inspection and polypectomy during insertion as compared to the patients undergoing traditional practice of careful inspection and polypectomy performed entirely during withdrawal of colonoscopy.

NCT03444090 Colon Polyp Colon Adenoma

1 Interventions

Name: Colon polypectomy

Description: For participants assigned into the experimental group, colon lumen is washed and the debris is suctioned as the colonoscopy is slowly inserted from rectum to cecum. Deliberate and systematic inspection of the mucosa is performed with adequate insufflation during both the insertion and withdrawal phases. Colon polyps with size <10 mm are removed as they are identified on insertion and withdrawal. Polyps with size >10 mm are removed only during withdrawal. For participants assigned into the control group, deliberate inspection and polyp removal are performed exclusively on colonoscopy withdrawal.During insertion, minimal mucosal inspection and insufflation are applied to efficiently advance the instrument into cecum.
Type: Procedure
Group Labels: 2

Insertion/withdrawal colon polypectomy Withdrawal colon polypectomy

Primary Outcomes

Description: Colon adenoma detection rate is defined as the proportion of colonoscopies where at least one adenoma is found.

Measure: Percentage of Participants With Detection of at Least One Adenoma Per Procedure

Time: During procedure, approximately one hour

Secondary Outcomes

Description: Mean colon adenoma per procedure is defined as the total number of adenomas detected divided by the number of colonoscopies.

Measure: Mean Colon Adenoma Per Colonoscopy

Time: During procedure, approximately one hour

Purpose: Treatment

Allocation: Randomized

Parallel Assignment

There is one SNP


1 Q260A

Colonoscopies will be performed by two experienced investigators by using a standard colonoscopy (CF-Q260AI or CF-Q260AL; Olympus Medical Systems Corp., Tokyo, Japan). --- Q260A ---

HPO Nodes